Oral, Slow-Release Ivermectin: Biting Back at Malaria Vectors

Trends Parasitol. 2017 Mar;33(3):156-158. doi: 10.1016/j.pt.2016.12.008. Epub 2017 Jan 6.

Abstract

Bellinger and colleagues offer an elegant twist for a promising new tool against malaria. This formulation is designed to release ivermectin, a mosquito-killing drug for 10 days after a single oral dose. This could reduce the vector population and serve as a complementary tool for malaria elimination.

Keywords: endectocide; ivermectin; malaria elimination; mass drug administration; slow-release; vector control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Administration, Oral
  • Animals
  • Delayed-Action Preparations / administration & dosage
  • Delayed-Action Preparations / pharmacokinetics
  • Delayed-Action Preparations / pharmacology
  • Humans
  • Insect Vectors / drug effects
  • Insecticides / administration & dosage
  • Insecticides / pharmacokinetics
  • Insecticides / pharmacology
  • Ivermectin / administration & dosage*
  • Ivermectin / pharmacokinetics
  • Ivermectin / pharmacology
  • Malaria / drug therapy
  • Malaria / prevention & control*
  • Mosquito Control / methods*

Substances

  • Delayed-Action Preparations
  • Insecticides
  • Ivermectin