Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

Kanika Aggarwal; Aniruddha Agarwal; Ankit Deokar; Sarakshi Mahajan; Ramandeep Singh; Reema Bansal; Aman Sharma; Mangat R Dogra; Vishali Gupta; OCTA Study Group

doi:10.1186/s12348-016-0122-z

Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

J Ophthalmic Inflamm Infect. 2017 Dec;7(1):3. doi: 10.1186/s12348-016-0122-z. Epub 2017 Jan 13.

Authors

Affiliations

¹ Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
² Ocular Imaging Research and Reading Center (OIRRC), Omaha, NE, 68105, USA.
³ Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
⁴ Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India. vishalisara@yahoo.co.in.

Abstract

Background: The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. OCTA images were analyzed for alterations in retinochoroidal microvasculature.

Results: Thirty-four eyes (24 patients; 10 with VKH and 14 with CSC) were included. OCTA en face images showed apparent areas of choriocapillaris flow void due to shadowing effect from overlying subretinal fluid and pigment epithelial detachment in CSC. However, eyes with VKH showed presence of true choriocapillaris flow void on OCTA that corresponded to choriocapillaris ischemia on ICGA.

Conclusions: OCTA is a useful tool to assess choriocapillaris ischemia in VKH and is helpful to differentiate it from CSC in the acute stage.

Keywords: Central serous chorioretinopathy; EDI-OCT; Indocyanine green angiography; Multimodal imaging; Optical coherence tomography angiography; Vogt-Koyanagi-Harada syndrome.