Association study between the neurexin-1 gene and tardive dyskinesia

Hum Psychopharmacol. 2017 Jan;32(1). doi: 10.1002/hup.2568.

Abstract

Objective: Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.

Methods: This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.

Results: We did not find these SNPs to be significantly associated with TD.

Conclusions: More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.

Keywords: antipsychotics; neurexin-1 (NRXN1); pharmacogenetic; schizophrenia (SCZ); tardive dyskinesia (TD).

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Calcium-Binding Proteins
  • Cell Adhesion Molecules, Neuronal / genetics*
  • Female
  • Genetic Association Studies / methods*
  • Humans
  • Male
  • Nerve Tissue Proteins / genetics*
  • Neural Cell Adhesion Molecules
  • Polymorphism, Single Nucleotide / genetics*
  • Schizophrenia / drug therapy
  • Schizophrenia / genetics*
  • Tardive Dyskinesia / chemically induced
  • Tardive Dyskinesia / genetics*
  • White People / genetics

Substances

  • Antipsychotic Agents
  • Calcium-Binding Proteins
  • Cell Adhesion Molecules, Neuronal
  • NRXN1 protein, human
  • Nerve Tissue Proteins
  • Neural Cell Adhesion Molecules

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