Microbe Hunting Hits Home

Ivaylo I Ivanov

doi:10.1016/j.chom.2017.02.010

Microbe Hunting Hits Home

Cell Host Microbe. 2017 Mar 8;21(3):282-285. doi: 10.1016/j.chom.2017.02.010.

Author

Ivaylo I Ivanov¹

Affiliation

¹ Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ii2137@cumc.columbia.edu.

Abstract

Ten years ago, we discovered that microbiota composition controls intestinal T cell homeostasis and alters T cell responses of mice in different animal facilities. Here I discuss how these discoveries, reported in Cell Host & Microbe in 2008, came to be and contributed to our understanding of microbiota immune effects.

Keywords: Jackson; SFB; Taconic; Th17 cells; germ-free mice; gut; immunomodulatory bacteria; microbiota; segmented filamentous bacteria.

MeSH terms

Animals
Gastrointestinal Microbiome*
Gastrointestinal Tract / immunology*
Gastrointestinal Tract / microbiology*
Homeostasis
Mice
T-Lymphocytes / immunology*

Abstract

MeSH terms

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