ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network

Cancer Cell. 2017 Mar 13;31(3):307-308. doi: 10.1016/j.ccell.2017.02.015.

Abstract

Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease with a relatively poorly understood pathogenesis. In this issue of Cancer Cell, Thirant and colleagues systematically examine unique transcriptional and functional effects of ETO2-GLIS2, an oncogenic fusion protein frequently encountered in AMKL, and elucidate a therapeutic vulnerability in this poor-prognosis leukemia.

Publication types

  • Comment

MeSH terms

  • Humans
  • Leukemia, Megakaryoblastic, Acute / drug therapy*
  • Oncogene Proteins, Fusion / metabolism
  • Transcription Factors / therapeutic use*

Substances

  • Oncogene Proteins, Fusion
  • Transcription Factors