Identification of a novel HLA allele, HLA-B*15:416, in a bone marrow hematopoietic stem cell donor

HLA. 2017 Jul;90(1):39-40. doi: 10.1111/tan.13014. Epub 2017 Mar 17.

Abstract

The novel HLA-B*15:416 allele differs from HLA-B*15:01:01:01 by a single nucleotide substitution at codon 114.

Keywords: HLA-B*15:416; new allele; sequence-based typing.

MeSH terms

  • Alleles*
  • Amino Acid Substitution
  • Base Sequence
  • Bone Marrow Transplantation
  • Codon / chemistry
  • Exons*
  • Gene Expression
  • Genotype
  • HLA-B15 Antigen / genetics*
  • HLA-B15 Antigen / immunology
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Humans
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Tissue Donors*

Substances

  • Codon
  • HLA-B15 Antigen