Abstract
Regulatory T cells play a critical role in preventing fetal organ-specific autoimmunity in humans. Autopsies of neonatal IPEX patients shortly after birth demonstrate chronic exocrine-dominant pancreatitis with tertiary lymphoid structures containing expanded oligoclonal T/B lymphocytes.
Publication types
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Case Reports
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoimmunity*
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Biomarkers
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Disease Models, Animal
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Fetal Development / immunology*
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Humans
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Immunohistochemistry
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Immunologic Deficiency Syndromes / diagnosis
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Immunologic Deficiency Syndromes / etiology
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Immunologic Deficiency Syndromes / metabolism
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Infant, Newborn
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Mice
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Mice, Transgenic
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Organ Specificity / immunology
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism