Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease

Ocul Immunol Inflamm. 2018;26(6):934-942. doi: 10.1080/09273948.2017.1285035. Epub 2017 Mar 21.

Abstract

Purpose: To demonstrate photoreceptor cell injury in Vogt-Koyanagi-Harada (VKH) disease.

Methods: The SD-OCT and FAF tests of 16 patients diagnosed with VKH disease that was followed up from the initial stage to the convalescent stage were reviewed.

Results: In the initial stage of VKH disease, there was hyperautofluerescence around the macular edema. In the convalescent stage of VKH disease, loss of photoreceptor and injury of RPE have been detected by OCT scan at the same area, which was corresponded with the abnormalities in FAF.

Conclusions: The VKH disease causes photoreceptor injury starting in the initial stage of the disease.

Keywords: Fundus autofluorescence; VKH disease; optical coherence tomography; photoreceptor; photoreceptor injury.

MeSH terms

  • Adult
  • Aged
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Macular Edema / diagnosis
  • Macular Edema / etiology*
  • Male
  • Middle Aged
  • Photoreceptor Cells / pathology*
  • Retinal Pigment Epithelium / pathology
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Uveomeningoencephalitic Syndrome / complications
  • Uveomeningoencephalitic Syndrome / diagnosis*