Relationships between acrylamide and glycidamide hemoglobin adduct levels and allergy-related outcomes in general US population, NHANES 2005-2006

Jing Guo; Dongdong Yu; Na Lv; Rongpan Bai; Chunjing Xu; Guangdi Chen; Weiming Cao

doi:10.1016/j.envpol.2017.03.016

Relationships between acrylamide and glycidamide hemoglobin adduct levels and allergy-related outcomes in general US population, NHANES 2005-2006

Environ Pollut. 2017 Jun:225:506-513. doi: 10.1016/j.envpol.2017.03.016. Epub 2017 Mar 18.

Authors

Jing Guo¹, Dongdong Yu¹, Na Lv¹, Rongpan Bai¹, Chunjing Xu², Guangdi Chen³, Weiming Cao⁴

Affiliations

¹ Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Institute of Environmental Health, Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: chenguangdi@zju.edu.cn.
⁴ School of Humanities and Social Sciences, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: cwm@zju.edu.cn.

PMID: 28325597
DOI: 10.1016/j.envpol.2017.03.016

Abstract

Background: Acrylamide-induced immunotoxicity and allergic dermatitis have been reported in animal experiments and clinical reports, respectively. However, epidemiological evidence from the general population is limited.

Objectives: The purpose of the present study was to estimate the associations between acrylamide exposure and allergy-related outcomes in the general US population.

Methods: A total of 6982 subjects were selected from the National Health and Nutrition Examination Survey 2005-2006 (NHANES). Internal exposure was measured by the hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA). Allergy-related outcomes including asthma, hay fever, allergy, itchy rash, sneeze, wheeze and eczema were obtained by self-administered questionnaires. Allergic sensitization was assessed by the total immunoglobulin E (IgE) levels. The associations of HbAA and HbGA quartiles with allergy-related outcomes were calculated using logistic regression models with multivariable adjustments. Analyses were additionally stratified according to age, gender and serum cotinine levels.

Results: When setting quartile 1 of HbAA as reference, the odds ratios (ORs) [95% confidence intervals (CIs)] of quartile 2 to 4 for eczema were 1.18 (0.79-1.76), 1.14 (0.73-1.78) and 1.58 (1.14-2.18), respectively (p_trend = 0.002). Individuals at the highest quartile of HbGA had significantly elevated likelihoods of itchy rash (OR = 1.37, 95% CI = 1.02-1.83, p_trend = 0.032) and eczema (OR = 1.45, 95% CI = 1.06-1.97, p_trend = 0.044). The stratification analyses indicated various results in different subgroups.

Conclusions: This study indicated significant associations between HbAA and HbGA levels and the likelihoods of allergy-related outcomes in the general US population, depending on age, gender and smoke exposure status. These findings suggested potential public health concerns for the widespread exposure to acrylamide.

Keywords: Acrylamide; Allergy; Glycidamide; Hemoglobin adducts; NHANES.

MeSH terms

Acrylamide / metabolism*
Acrylamide / toxicity
Adult
Animals
Asthma
Environmental Exposure / analysis
Environmental Exposure / statistics & numerical data*
Epoxy Compounds / metabolism*
Epoxy Compounds / toxicity
Female
Hemoglobins / metabolism
Humans
Hypersensitivity
Logistic Models
Male
Middle Aged
Nutrition Surveys
Odds Ratio
Rhinitis, Allergic, Seasonal
United States

Substances

Epoxy Compounds
Hemoglobins
Acrylamide
glycidamide