Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases

Neurobiol Aging. 2017 Jan:49:215.e9-215.e10. doi: 10.1016/j.neurobiolaging.2016.09.017. Epub 2016 Oct 3.

Abstract

We investigated the role of mortalin (HSPA9) and its interaction with other mitochondria-related genes (parkin, PINK1, DJ1, and COQ2) as a risk factor for Parkinson's disease (PD) and Alzheimer's disease (AD) in 500 PD, 400 AD, and 500 control subjects. The HSPA9 variants identified by direct sequencing or its interaction with other genes assessed by genetic risk scores did not show a significant association with PD or AD risk. Our findings did not provide a strong evidence for the role of HAPA9 and its interaction with other mitochondria-related genes as a genetic risk factor for PD or AD.

Keywords: Alzheimer's disease; Genetic variation; Mitochondria; Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkyl and Aryl Transferases / genetics
  • Alzheimer Disease / genetics*
  • Epistasis, Genetic / genetics*
  • Female
  • Genetic Association Studies*
  • Genetic Variation / genetics*
  • HSP70 Heat-Shock Proteins / genetics*
  • Humans
  • Male
  • Mitochondria / genetics*
  • Mitochondrial Proteins / genetics*
  • Parkinson Disease / genetics*
  • Protein Deglycase DJ-1 / genetics
  • Protein Kinases / genetics
  • Risk
  • Risk Factors
  • Ubiquitin-Protein Ligases / genetics

Substances

  • HSP70 Heat-Shock Proteins
  • HSPA9 protein, human
  • Mitochondrial Proteins
  • Ubiquitin-Protein Ligases
  • parkin protein
  • Alkyl and Aryl Transferases
  • 4-hydroxybenzoate polyprenyltransferase
  • Protein Kinases
  • PTEN-induced putative kinase
  • PARK7 protein, human
  • Protein Deglycase DJ-1