Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection

Micheál Mac Aogáin; Helen Miajlovic; Geraldine Moloney; Sanjay H Chotirmall; Thomas R Rogers; Stephen G J Smith

doi:10.1099/jmmcr.0.005061

Identification of a novel sequence type of Escherichia coli as the causative agent of pyelonephritis and bloodstream infection

JMM Case Rep. 2016 Oct 31;3(5):e005061. doi: 10.1099/jmmcr.0.005061. eCollection 2016 Oct.

Authors

Micheál Mac Aogáin¹, Helen Miajlovic¹, Geraldine Moloney¹, Sanjay H Chotirmall², Thomas R Rogers¹, Stephen G J Smith¹

Affiliations

¹ Department of Clinical Microbiology, Sir Patrick Dun Research Laboratory, School of Medicine, Trinity College , Dublin , Ireland.
² Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Abstract

Introduction: Globally, extra-intestinal pathogenic Escherichia coli are one of the predominant causative agents of bacteraemia.

Case presentation: This case report outlines a presentation of community-acquired pyelonephritis and secondary bloodstream infection in an 81-year-old man. Laboratory investigations revealed that the causative isolate was a multi-drug-resistant E. coli of a novel multi-locus sequence type. This sequence type (ST) was designated ST-458 and was most closely related to the globally prevalent ST-131 lineage.

Conclusion: This is the first report of a novel E. coli ST, ST-458, which caused pyelonephritis and bacteraemia.

Keywords: Antimicrobial resistance; Escherichia coli ST-458; Infected renal parenchymal cyst; Pyelonephritis; Virulence factors; bacteraemia.

Publication types

Case Reports