Abstract
The effects of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or ganciclovir, administered during the immediate posttransplant period to dogs given total-body irradiation and autologous marrow transplants were studied. Doses of ganciclovir of 3.0 mg/kg (body weight) per day were well tolerated without detectable delay in hematopoietic recovery, whereas doses of 5.0 mg/kg per day were associated with delayed platelet recovery.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acyclovir / analogs & derivatives*
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Acyclovir / therapeutic use
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Acyclovir / toxicity
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Animals
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Antiviral Agents / therapeutic use
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Antiviral Agents / toxicity*
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Bone Marrow Transplantation*
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Cyclosporins / therapeutic use
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Cytomegalovirus Infections / prevention & control*
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Dogs
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Ganciclovir
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Immunosuppression Therapy
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Platelet Count / drug effects
Substances
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Antiviral Agents
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Cyclosporins
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Ganciclovir
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Acyclovir