Immunodeficiencies Associated with Abnormal Newborn Screening for T Cell and B Cell Lymphopenia

Soma Jyonouchi; Artemio M Jongco; Jennifer Puck; Kathleen E Sullivan

doi:10.1007/s10875-017-0388-4

Immunodeficiencies Associated with Abnormal Newborn Screening for T Cell and B Cell Lymphopenia

J Clin Immunol. 2017 May;37(4):363-374. doi: 10.1007/s10875-017-0388-4. Epub 2017 Mar 28.

Authors

Soma Jyonouchi¹, Artemio M Jongco², Jennifer Puck³, Kathleen E Sullivan⁴

Affiliations

¹ Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
² Division of Allergy and Immunology, Cohen Children's Medical Center of New York, Hofstra Northwell School of Medicine, Hempstead, NY, USA.
³ Division of Allergy, Immunology and Blood and Marrow Transplantation, Department of Pediatrics, University of California San Francisco, and UCSF Benioff Children's Hospital, San Francisco, CA, USA.
⁴ Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. sullivak@mail.med.upenn.edu.

PMID: 28353166
DOI: 10.1007/s10875-017-0388-4

Abstract

Newborn screening for SCID has revealed the association of low T cells with a number of unexpected syndromes associated with low T cells, some of which were not appreciated to have this feature. This review will discuss diagnostic approaches and the features of some of the syndromes likely to be encountered following newborn screening for immune deficiencies.

Keywords: Immunology; Low T cells; NBS; Newborn screen.

Publication types

Review

MeSH terms

B-Lymphocytes / pathology*
Humans
Immunologic Deficiency Syndromes / diagnosis*
Infant, Newborn
Lymphopenia / diagnosis*
Neonatal Screening
Severe Combined Immunodeficiency / diagnosis*
T-Lymphocytes / pathology*