Abstract
Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
Keywords:
6q22 deletion; CNS = central nervous system; FFPE = formalin-fixed, paraffin-embedded; GOPC; ROS1; RT-PCR = reverse transcriptase–polymerase chain reaction; RTK = receptor tyrosine kinase; oncology; receptor protein-tyrosine kinases.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Brain / diagnostic imaging
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Brain / pathology
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Brain / surgery
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Brain Neoplasms / diagnostic imaging
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Brain Neoplasms / genetics*
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Brain Neoplasms / pathology
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Brain Neoplasms / surgery*
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Carrier Proteins / genetics*
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Child, Preschool
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Female
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Glioma / diagnostic imaging
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Glioma / genetics*
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Glioma / pathology
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Glioma / surgery*
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Golgi Matrix Proteins
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Humans
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Membrane Proteins / genetics*
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Membrane Transport Proteins
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Neoplasm Grading
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Protein-Tyrosine Kinases / genetics*
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Proto-Oncogene Proteins / genetics*
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Sequence Deletion
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Survivors
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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GOPC protein, human
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Golgi Matrix Proteins
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Membrane Proteins
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Membrane Transport Proteins
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Proto-Oncogene Proteins
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Protein-Tyrosine Kinases
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ROS1 protein, human