Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis

Clin Infect Dis. 2017 Jul 15;65(2):338-341. doi: 10.1093/cid/cix318.

Abstract

Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.

Keywords: coccidioidomycosis; corticosteroids; meningitis; stroke; vasculitis.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / adverse effects
  • Adrenal Cortex Hormones / therapeutic use*
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Coccidioidomycosis / drug therapy*
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Meningitis, Fungal / drug therapy*
  • Middle Aged
  • Retrospective Studies
  • Vasculitis / complications
  • Vasculitis / drug therapy
  • Young Adult

Substances

  • Adrenal Cortex Hormones