Applications of Synthetic Organic Tetrasulfides as H2S Donors

Matthew M Cerda; Matthew D Hammers; Mary S Earp; Lev N Zakharov; Michael D Pluth

doi:10.1021/acs.orglett.7b00858

Applications of Synthetic Organic Tetrasulfides as H₂S Donors

Org Lett. 2017 May 5;19(9):2314-2317. doi: 10.1021/acs.orglett.7b00858. Epub 2017 Apr 25.

Authors

Matthew M Cerda¹, Matthew D Hammers¹, Mary S Earp¹, Lev N Zakharov¹, Michael D Pluth¹

Affiliation

¹ Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, University of Oregon , Eugene, Oregon 97403, United States.

Abstract

In an effort to expand the availability of simple polysulfides for H₂S donation, we report here the synthesis and H₂S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H₂S in a first-order dependence on reduced glutathione (GSH) and release more H₂S than the commonly used trisulfide DATS.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Grants and funding

R01 GM113030/GM/NIGMS NIH HHS/United States