Somatic BRCA2 bi-allelic loss in the primary prostate cancer was associated to objective response to PARPi in a sporadic CRPC patient

Ann Oncol. 2017 May 1;28(5):1158-1159. doi: 10.1093/annonc/mdx067.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • BRCA2 Protein / genetics
  • Benzimidazoles / therapeutic use*
  • Genes, BRCA2*
  • Germ-Line Mutation
  • Humans
  • Loss of Heterozygosity*
  • Male
  • Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use*
  • Prostatic Neoplasms, Castration-Resistant / drug therapy*
  • Prostatic Neoplasms, Castration-Resistant / genetics*

Substances

  • BRCA2 Protein
  • BRCA2 protein, human
  • Benzimidazoles
  • Poly(ADP-ribose) Polymerase Inhibitors
  • veliparib