Acute eosinophilic pneumonia following artenimol-piperaquine exposure

J Travel Med. 2017 Sep 1;24(5). doi: 10.1093/jtm/tax023.

Abstract

Acute eosinophilic pneumonia (AEP) has been reported following chloroquine or mefloquine exposure, both structurally related to piperaquine. We report a case of AEP with typical CT scan patterns, hypereosinophilia in blood (9.8 109/l), and bronchoalveolar lavage (78% of 600 000 cells/ml), 10 days after artenimol-piperaquine exposure in a 26-year-old man.

Keywords: Acute eosinophilic pneumonia; artenimol; hypereosinophilia; malaria; piperaquine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimalarials / administration & dosage
  • Antimalarials / adverse effects*
  • Artemisinins / administration & dosage
  • Artemisinins / adverse effects*
  • Diagnosis, Differential
  • Humans
  • Malaria / prevention & control*
  • Male
  • Pulmonary Eosinophilia / blood
  • Pulmonary Eosinophilia / chemically induced
  • Pulmonary Eosinophilia / diagnosis*
  • Pulmonary Eosinophilia / diagnostic imaging
  • Quinolines / administration & dosage
  • Quinolines / adverse effects*
  • Tomography, X-Ray Computed
  • Travel*

Substances

  • Antimalarials
  • Artemisinins
  • Artenimol-R
  • Quinolines
  • piperaquine