Severe neonatal alloimmune thrombocytopenia caused by maternal sensitization against a new low-frequency alloantigen (Dom^b ) located on platelet glycoprotein IIIa

Transfusion. 2017 Jul;57(7):1847-1848. doi: 10.1111/trf.14160. Epub 2017 May 18.

Authors

Mia J Sullivan¹, Randy Kuhlmann², Julie A Peterson³, Brian R Curtis^{1

3}

Affiliations

¹ Platelet & Neutrophil Immunology Lab.
² Aurora West Allis Memorial Hospital Women's Pavilion, Milwaukee, Wisconsin.
³ Blood Research Institute, BloodCenter of Wisconsin.

PMID: 28518345
DOI: 10.1111/trf.14160

No abstract available

MeSH terms

Amniocentesis
Antibody Specificity
Antigens, Human Platelet / genetics
Antigens, Human Platelet / immunology*
Female
Humans
Immunity, Maternally-Acquired / immunology*
Immunization
Immunoglobulins, Intravenous / therapeutic use
Infant, Newborn
Infant, Premature, Diseases / etiology*
Infant, Premature, Diseases / immunology
Infant, Premature, Diseases / therapy
Integrin alpha2
Integrin beta3 / genetics
Integrin beta3 / immunology*
Isoantigens / genetics
Isoantigens / immunology*
Male
Mutagenesis, Site-Directed
Mutation, Missense*
Platelet Count
Platelet Transfusion
Point Mutation*
Polymorphism, Single Nucleotide*
Pregnancy
Recombinant Proteins / immunology
Thrombocytopenia, Neonatal Alloimmune / etiology*
Thrombocytopenia, Neonatal Alloimmune / immunology
Thrombocytopenia, Neonatal Alloimmune / therapy

Substances

Antigens, Human Platelet
Dom(b) alloantigen, human
ITGA2B protein, human
ITGB3 protein, human
Immunoglobulins, Intravenous
Integrin alpha2
Integrin beta3
Isoantigens
Recombinant Proteins