Covalent Probe Finds Carboxylic Acid

Alexander Jones; Xiaoyun Zhang; Xiaoguang Lei

doi:10.1016/j.chembiol.2017.05.003

Covalent Probe Finds Carboxylic Acid

Cell Chem Biol. 2017 May 18;24(5):537-539. doi: 10.1016/j.chembiol.2017.05.003.

Authors

Alexander Jones¹, Xiaoyun Zhang¹, Xiaoguang Lei²

Affiliations

¹ Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing 100871, China; Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
² Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing 100871, China; Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address: xglei@pku.edu.cn.

PMID: 28525765
DOI: 10.1016/j.chembiol.2017.05.003

Abstract

In this issue of Cell Chemical Biology, Martín-Gago et al. (2017a) disclose a new strategy for the selective covalent targeting of binding site carboxylic acids within the proteome using the isoxazolium salt as a warhead. This discovery paves the way for developing new protein ligation methods as well as covalent drug candidates.

MeSH terms

Binding Sites
Carboxylic Acids / chemistry*
Carboxylic Acids / metabolism
Isoxazoles / chemistry
Molecular Probes / chemistry*
Proteome / chemistry
Proteome / metabolism

Substances

Carboxylic Acids
Isoxazoles
Molecular Probes
Proteome