Genetically engineered mouse models of melanoma

Cancer. 2017 Jun 1;123(S11):2089-2103. doi: 10.1002/cncr.30684.

Abstract

Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089-103. © 2017 American Cancer Society.

Keywords: carcinogen; genetically engineered mice; melanoma; mouse models; ultraviolet (UV) radiation.

Publication types

  • Review
  • Research Support, N.I.H., Intramural
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Genetic Engineering
  • Melanoma / genetics*
  • Mice*
  • Mice, Knockout
  • Mice, Transgenic
  • Skin Neoplasms / genetics*
  • Transcriptome