Functional evolution of Lepidoptera olfactory receptors revealed by deorphanization of a moth repertoire

Nat Commun. 2017 Jun 5:8:15709. doi: 10.1038/ncomms15709.

Abstract

Insects detect their hosts or mates primarily through olfaction, and olfactory receptors (ORs) are at the core of odorant detection. Each species has evolved a unique repertoire of ORs whose functional properties are expected to meet its ecological needs, though little is known about the molecular basis of olfaction outside Diptera. Here we report a pioneer functional analysis of a large array of ORs in a lepidopteran, the herbivorous pest Spodoptera littoralis. We demonstrate that most ORs are narrowly tuned to ubiquitous plant volatiles at low, relevant odorant titres. Our phylogenetic analysis highlights a basic conservation of function within the receptor repertoire of Lepidoptera, across the expansive evolutionary radiation of different major clades. Our study provides a reference for further studies of olfactory mechanisms in Lepidoptera, a historically crucial insect order in olfactory research.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Arthropod Antennae / metabolism*
  • Dose-Response Relationship, Drug
  • Drosophila
  • Female
  • Insect Proteins / genetics*
  • Likelihood Functions
  • Male
  • Models, Statistical
  • Odorants
  • Olfactory Receptor Neurons / metabolism*
  • Phylogeny
  • Receptors, Odorant / genetics*
  • Smell*
  • Spodoptera / physiology*

Substances

  • Insect Proteins
  • Receptors, Odorant