β2-adrenergic receptors in inflammation and vascular complications of diabetes

Daniel L Galvan; Farhad R Danesh

doi:10.1016/j.kint.2017.03.024

β₂-adrenergic receptors in inflammation and vascular complications of diabetes

Kidney Int. 2017 Jul;92(1):14-16. doi: 10.1016/j.kint.2017.03.024.

Authors

Daniel L Galvan¹, Farhad R Danesh²

Affiliations

¹ Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
² Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA. Electronic address: fdanesh@mdanderson.org.

PMID: 28646990
DOI: 10.1016/j.kint.2017.03.024

Abstract

The cross talk between the immune and nervous systems is critical not only for maintaining normal homeostasis but also for the progression of a variety of inflammatory diseases. Macrophage activation and β₂-adrenergic receptors are known to play important roles in facilitating this communication between these 2 systems. Using an integrated in vitro and in vivo study, Noh et al. reveal that β₂-adrenergic receptor agonists exhibit protective effects against the vascular complications of diabetes. The protective effects of β₂-adrenergic receptor agonists seem to be dependent on a β-arrestin2/inhibitor of kappa B/nuclear factor-κB signaling pathway.

Publication types

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MeSH terms

Diabetes Complications
Humans
Inflammation*
NF-kappa B
Receptors, Adrenergic
Signal Transduction*

Substances

NF-kappa B
Receptors, Adrenergic