Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Irina Matei; Han Sang Kim; David Lyden

doi:10.1016/j.cell.2017.06.047

Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Cell. 2017 Jul 13;170(2):223-225. doi: 10.1016/j.cell.2017.06.047.

Authors

Irina Matei¹, Han Sang Kim², David Lyden³

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA. Electronic address: irm2224@med.cornell.edu.
² Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Division of Medical Oncology, Departments of Internal Medicine and Pharmacology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
³ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: dcl2001@med.cornell.edu.

PMID: 28708994
DOI: 10.1016/j.cell.2017.06.047

Abstract

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

Publication types

Comment

MeSH terms

Exosomes / genetics
Humans
Neoplasms / genetics*
RNA*

Substances

RNA