3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis

Cell. 2017 Jul 13;170(2):367-381.e20. doi: 10.1016/j.cell.2017.06.029.

Abstract

High-order chromatin structure plays important roles in gene expression regulation. Knowledge of the dynamics of 3D chromatin structures during mammalian embryo development remains limited. We report the 3D chromatin architecture of mouse gametes and early embryos using an optimized Hi-C method with low-cell samples. We find that mature oocytes at the metaphase II stage do not have topologically associated domains (TADs). In sperm, extra-long-range interactions (>4 Mb) and interchromosomal interactions occur frequently. The high-order structures of both the paternal and maternal genomes in zygotes and two-cell embryos are obscure but are gradually re-established through development. The establishment of the TAD structure requires DNA replication but not zygotic genome activation. Furthermore, unmethylated CpGs are enriched in A compartment, and methylation levels are decreased to a greater extent in A compartment than in B compartment in embryos. In summary, the global reprogramming of chromatin architecture occurs during early mammalian development.

Keywords: Hi-C; TAD; chromatin structure; compartment; embryo development; epigenetic; gamete; zygotic genome activation.

MeSH terms

  • Animals
  • Chromatin / chemistry
  • Chromatin / metabolism*
  • CpG Islands
  • DNA Methylation
  • DNA Replication
  • Embryo, Mammalian / chemistry
  • Embryo, Mammalian / metabolism*
  • Embryonic Development*
  • Epigenesis, Genetic
  • Female
  • Germ Cells / metabolism
  • Male
  • Metaphase
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Oocytes / cytology
  • Spermatozoa / metabolism
  • Zygote / metabolism

Substances

  • Chromatin