Linking chanelopathies with endoplasmic reticulum associated degradation

Channels (Austin). 2017 Nov 2;11(6):499-501. doi: 10.1080/19336950.2017.1357944. Epub 2017 Aug 18.
No abstract available

Keywords: ERAD; ROMK; Saccharomyces cerevisiae; Type II Bartter Syndrome; proteasome; protein quality control; yeast.

MeSH terms

  • Amino Acid Substitution
  • Bartter Syndrome / genetics*
  • Cell Membrane / metabolism
  • Endoplasmic Reticulum-Associated Degradation*
  • HEK293 Cells
  • Humans
  • Mutant Proteins / genetics
  • Mutation
  • Potassium Channels, Inwardly Rectifying / genetics
  • Potassium Channels, Inwardly Rectifying / metabolism*
  • Protein Aggregation, Pathological / metabolism
  • Protein Conformation, beta-Strand
  • Protein Stability
  • Saccharomyces cerevisiae / genetics
  • Structure-Activity Relationship

Substances

  • Mutant Proteins
  • Potassium Channels, Inwardly Rectifying