Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors

D S Lebedev; I A Ivanov; E V Kryukova; V G Starkov; V I Tsetlin; Yu N Utkin

doi:10.1134/S1607672917030127

Arginine derivatives of dicarboxylic acids from the parotid gland secretions of common toad Bufo bufo-New agonists of ionotropic γ-aminobutyric acid receptors

Dokl Biochem Biophys. 2017 May;474(1):178-182. doi: 10.1134/S1607672917030127. Epub 2017 Jul 20.

Authors

D S Lebedev¹, I A Ivanov², E V Kryukova², V G Starkov², V I Tsetlin², Yu N Utkin^{2

3}

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. dmitry-1@bk.ru.
² Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.
³ The National University of Science and Technology MISiS, Moscow, Russia.

PMID: 28726106
DOI: 10.1134/S1607672917030127

Abstract

Compounds activating γ-aminobutyric acid type A receptor were isolated from the toad Bufo bufo venom as a result of chromatographic separation. Analysis of the structure of these compounds by mass spectrometry and nuclear magnetic resonance showed that they are arginine derivatives of dicarboxylic acids and represent suberylarginine, pimeloylarginine, and adipoylarginine.

MeSH terms

Animals
Arginine / chemistry*
Bufo bufo*
Dicarboxylic Acids / chemistry*
Dicarboxylic Acids / metabolism
Dicarboxylic Acids / pharmacology*
GABA-A Receptor Agonists / chemistry*
GABA-A Receptor Agonists / metabolism
GABA-A Receptor Agonists / pharmacology*
HEK293 Cells
Humans
Ligands
Parotid Gland / metabolism*
Receptors, GABA-A / metabolism*

Substances

Dicarboxylic Acids
GABA-A Receptor Agonists
Ligands
Receptors, GABA-A
Arginine