Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H Indik; Raymond L Woosley

doi:10.1016/j.ccep.2010.06.001

Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Card Electrophysiol Clin. 2010 Sep;2(3):341-358. doi: 10.1016/j.ccep.2010.06.001.

Authors

Julia H Indik¹, Raymond L Woosley²

Affiliations

¹ Department of Medicine, Sarver Heart Center, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724-5037, USA.
² Department of Medicine, Sarver Heart Center, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724-5037, USA; The Critical Path Institute, 1730 East River Road, #200, Tucson, AZ 85718, USA.

PMID: 28770794
DOI: 10.1016/j.ccep.2010.06.001

Abstract

This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.