IL7RA polymorphisms are not associated with AIDS progression

Eur J Clin Invest. 2017 Oct;47(10):719-727. doi: 10.1111/eci.12797. Epub 2017 Sep 2.

Abstract

Background: Our aim was to determine whether α-chain of the IL-7 receptor (IL7RA) polymorphisms (rs10491434, rs6897932 and rs987106) are associated with the clinical pattern of AIDS progression in ART-naïve HIV-infected patients.

Materials and methods: We carried out a cross-sectional study in 673 HIV-infected patients who were classified into three groups according to the clinical pattern of AIDS progression (188 long-term nonprogressors (LTNPs), 334 moderate progressors (MPs) and 151 rapid progressors (RPs)). Additionally, 134 healthy blood donors participated as a Control-group. We selected three IL7RA polymorphisms located at three regulatory regions [rs6897932 (exon 6), rs987106 (intronic region) and rs10491434 (3'UTR)]. DNA genotyping was performed using Sequenom's MassARRAY platform.

Results: The Control-group and all HIV-infected patients had similar age and percentage of males. LTNP-group was older at HIV diagnosis and at the inclusion in the study and had higher percentage of intravenous drug users (IDU) (P < 0·001). Besides, LTNP-group had lower proportion of male patients and homosexual HIV transmission than MP and RP groups (P < 0·001). Moreover, similar values of allelic, genotypic and haplotype frequencies for IL7RA polymorphisms were found between healthy controls and HIV-infected patients (P > 0·05), and among different subgroups of HIV patients according to AIDS progression (LTNPs, MPs and RPs) (P > 0·05). The adjusted logistic regression did not show any significant association between IL7RA polymorphisms and AIDS progression.

Conclusions: IL7RA polymorphisms (rs6897932, rs987106 and rs10491434) were not associated with AIDS progression in Spanish population. Therefore, IL7RA polymorphisms do not seem to help us to understand HIV pathogenesis in untreated HIV-infected patients with different clinical evolution.

Keywords: IL7RA; Acquired immunodeficiency syndrome; long-term nonprogressors; progression; single nucleotide polymorphisms.

Publication types

  • Comparative Study

MeSH terms

  • Acquired Immunodeficiency Syndrome / diagnosis
  • Acquired Immunodeficiency Syndrome / genetics
  • Acquired Immunodeficiency Syndrome / mortality
  • Adult
  • Age Factors
  • Cross-Sectional Studies
  • Disease Progression
  • Female
  • Gene Expression Regulation*
  • HIV Infections / diagnosis
  • HIV Infections / genetics*
  • HIV Infections / mortality*
  • Humans
  • Interleukin-7 Receptor alpha Subunit / genetics*
  • Logistic Models
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Reference Values
  • Risk Assessment
  • Sensitivity and Specificity
  • Sex Factors
  • Spain
  • Survival Analysis

Substances

  • IL7R protein, human
  • Interleukin-7 Receptor alpha Subunit