Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele

Marco Túlio Gualberto Cintra; Rafaela Teixeira Ávila; Thayana Oliveira Soares; Luciana Cristina Matos Cunha; Katia Daniela Silveira; Edgar Nunes de Moraes; Kaique Roger Simas; Renato Bragança Fernandes; Denise Utsch Gonçalves; Nilton Alves de Rezende; Maria Aparecida Camargos Bicalho

doi:10.1002/gps.4773

Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele

Int J Geriatr Psychiatry. 2018 Feb;33(2):e221-e227. doi: 10.1002/gps.4773. Epub 2017 Aug 22.

Affiliations

¹ Geriatric doctor of Clinical Hospital of Universidade Federal de MInas Gerais, Belo Horizonte, Brazil.
² Neuropsychologist of Clinical Hospital of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
³ Molecular Medicine Postgraduate Program of Universidade Federal de Mina Gerais, Belo Horizonte, Brazil.
⁴ Speech therapist of Clinical Hospital of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
⁵ Department of Biochemistry and Immunology of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
⁶ Department of Medical Clinic of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
⁷ Medicine Student of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
⁸ Department of Ophthalmology and Otorhinolaryngology of Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

PMID: 28833437
DOI: 10.1002/gps.4773

Abstract

Objective: To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD).

Methods: This is a cross-sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real-time PCR technique.

Results: Sixty-five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment.

Conclusion: Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε-4 allele.

Keywords: Alzheimer's disease; apolipoproteins E; auditory evoked potentials; brain-derived neurotrophic factor; mild cognitive impairment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Alleles
Alzheimer Disease / diagnosis*
Alzheimer Disease / etiology
Alzheimer Disease / physiopathology
Apolipoproteins E / genetics*
Brain-Derived Neurotrophic Factor / genetics*
Case-Control Studies
Cognitive Dysfunction / diagnosis*
Cognitive Dysfunction / genetics
Cognitive Dysfunction / physiopathology
Cross-Sectional Studies
Evoked Potentials, Auditory / physiology*
Female
Genotype
Humans
Male
Neuropsychological Tests

Substances

Apolipoproteins E
Brain-Derived Neurotrophic Factor
BDNF protein, human