Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8+ cytotoxic T cells

Falk Heidenreich; Elke Rücker-Braun; Juliane S Walz; Anne Eugster; Denise Kühn; Sevina Dietz; Annika Nelde; Antje Tunger; Rebekka Wehner; Cornelia S Link; Jan M Middeke; Friedrich Stölzel; Torsten Tonn; Stefan Stevanovic; Hans-Georg Rammensee; Ezio Bonifacio; Michael Bachmann; Matthias Zeis; Gerhard Ehninger; Martin Bornhäuser; Johannes Schetelig; Marc Schmitz

doi:10.3324/haematol.2017.167312

Mass spectrometry-based identification of a naturally presented receptor tyrosine kinase-like orphan receptor 1-derived epitope recognized by CD8⁺ cytotoxic T cells

Haematologica. 2017 Nov;102(11):e460-e464. doi: 10.3324/haematol.2017.167312. Epub 2017 Aug 24.

Authors

Falk Heidenreich^{1

2}, Elke Rücker-Braun^{2

3}, Juliane S Walz⁴, Anne Eugster³, Denise Kühn³, Sevina Dietz³, Annika Nelde^{4

5}, Antje Tunger^{6

7}, Rebekka Wehner^{6

7}, Cornelia S Link^{2

3}, Jan M Middeke², Friedrich Stölzel², Torsten Tonn⁸, Stefan Stevanovic^{5

9

10}, Hans-Georg Rammensee^{5

9

10}, Ezio Bonifacio³, Michael Bachmann^{3

7

10

11

12}, Matthias Zeis¹³, Gerhard Ehninger^{2

3

7

10

11}, Martin Bornhäuser^{2

3

7

10

11}, Johannes Schetelig^{14

2}, Marc Schmitz^{3

6

7

10

11}

Affiliations

¹ DKMS German Bone Marrow Donor Center, Clinical Trials Unit, Dresden, Germany falk.heidenreich@uniklinikum-dresden.de.
² Department of Medicine I, University Hospital of Dresden, Germany.
³ Center for Regenerative Therapies Dresden, TU Dresden, Germany.
⁴ Department of Hematology and Oncology, University of Tübingen, Germany.
⁵ Department of Immunology, Institute for Cell Biology, University of Tübingen, Germany.
⁶ Institute of Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Germany.
⁷ National Center for Tumor Diseases, University Hospital Carl Gustav Carus, TU Dresden, Germany.
⁸ German Red Cross Blood Donation Service North-East, Dresden, Germany.
⁹ German Cancer Consortium (DKTK), Tübingen, Germany.
¹⁰ German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹¹ German Cancer Consortium (DKTK), Dresden, Germany.
¹² Department of Radioimmunology, Institute of Radiopharmaceutical Cancer Research, Helmholtz Center Dresden-Rossendorf, Dresden, Germany.
¹³ Städtisches Krankenhaus Kiel, Germany.
¹⁴ DKMS German Bone Marrow Donor Center, Clinical Trials Unit, Dresden, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antigen Presentation / immunology*
Epitope Mapping* / methods
Epitopes, T-Lymphocyte / immunology*
Epitopes, T-Lymphocyte / metabolism
Humans
Immunotherapy, Adoptive
Mass Spectrometry* / methods
Peptides / immunology
Receptor Tyrosine Kinase-like Orphan Receptors / immunology*
Receptor Tyrosine Kinase-like Orphan Receptors / metabolism
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Cytotoxic / metabolism

Substances

Epitopes, T-Lymphocyte
Peptides
Receptor Tyrosine Kinase-like Orphan Receptors