Spontaneous nasal perforation in a bevacizumab-treated patient with metastatic breast cancer

Breast J. 2017 Nov;23(6):745-746. doi: 10.1111/tbj.12913. Epub 2017 Aug 27.

Abstract

Nasal septum perforation in patients with cancer receiving systemic therapy is rare, and its association with bevacizumab use has described recently in the literature. Here, we report the case of a 34-year-old woman with hormone-sensitive, HER-2/neu negative, metastatic breast cancer who develope a nasal septum perforation during the treatment with paclitaxel and bevacizumab.

Keywords: bevacizumab; breast cancer; nasal septum perforation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / adverse effects
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Bevacizumab / administration & dosage
  • Bevacizumab / adverse effects
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / secondary
  • Nasal Septal Perforation / chemically induced
  • Nasal Septal Perforation / diagnosis*
  • Neoplasm Metastasis
  • Paclitaxel / administration & dosage
  • Paclitaxel / adverse effects

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Paclitaxel