In the Hunger Games, the Winner Takes Everything

Franziska Püschel; Cristina Muñoz-Pinedo

doi:10.1016/j.tibs.2017.08.004

In the Hunger Games, the Winner Takes Everything

Trends Biochem Sci. 2017 Oct;42(10):763-764. doi: 10.1016/j.tibs.2017.08.004. Epub 2017 Aug 28.

Authors

Franziska Püschel¹, Cristina Muñoz-Pinedo²

Affiliations

¹ Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
² Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. Electronic address: cmunoz@idibell.cat.

PMID: 28869131
DOI: 10.1016/j.tibs.2017.08.004

Abstract

Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activation in the loser cells triggers their engulfment and elimination by winner cells, which endure starvation.

Keywords: AMPK; cancer metabolism; cell death; entosis; glucose; starvation.

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MeSH terms

AMP-Activated Protein Kinases*
Cell Death
Glucose
Humans
Hunger*

Substances

AMP-Activated Protein Kinases
Glucose