Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia

Leuk Lymphoma. 2018 Apr;59(4):1008-1011. doi: 10.1080/10428194.2017.1365853. Epub 2017 Sep 18.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Genes, Immunoglobulin Heavy Chain / genetics*
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Immunoglobulin Variable Region / genetics
  • Leukemia, Hairy Cell / drug therapy*
  • Leukemia, Hairy Cell / genetics
  • MAP Kinase Kinase 1 / genetics*
  • Male
  • Middle Aged
  • Mutation
  • Protein Kinase Inhibitors / therapeutic use*
  • Pyridones / therapeutic use*
  • Pyrimidinones / therapeutic use*
  • Treatment Outcome

Substances

  • Immunoglobulin Heavy Chains
  • Immunoglobulin Variable Region
  • Protein Kinase Inhibitors
  • Pyridones
  • Pyrimidinones
  • trametinib
  • MAP Kinase Kinase 1
  • MAP2K1 protein, human