Direct Palladium-Catalyzed Carbonylative Transformation of Allylic Alcohols and Related Derivatives

Org Lett. 2017 Oct 6;19(19):5474-5477. doi: 10.1021/acs.orglett.7b02801. Epub 2017 Sep 18.

Abstract

A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols for the synthesis of β,γ-unsaturated carboxylic acids has been developed. With formic acid as the CO source, various allylic alcohols were conveniently transformed into the corresponding β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity. The reaction was performed under mild conditions; toxic CO gas manipulation and high-pressure equipment were avoided in this procedure.

Publication types

  • Research Support, Non-U.S. Gov't