A Tale of Two Genes: Microglial Apoe and Trem2

Anna A Pimenova; Edoardo Marcora; Alison M Goate

doi:10.1016/j.immuni.2017.08.015

A Tale of Two Genes: Microglial Apoe and Trem2

Immunity. 2017 Sep 19;47(3):398-400. doi: 10.1016/j.immuni.2017.08.015.

Authors

Anna A Pimenova¹, Edoardo Marcora², Alison M Goate³

Affiliations

¹ Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
³ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: alison.goate@mssm.edu.

PMID: 28930654
DOI: 10.1016/j.immuni.2017.08.015

Abstract

Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.

Publication types

Comment

MeSH terms

Aging
Alzheimer Disease
Apolipoproteins E*
Brain
Humans
Microglia / immunology*

Substances

Apolipoproteins E

Grants and funding

RF1 AG054011/AG/NIA NIH HHS/United States