Optic Pathway Gliomas Secondary to Neurofibromatosis Type 1

Shannon Jeanine Beres; Robert A Avery

doi:10.1016/j.spen.2017.04.006

Optic Pathway Gliomas Secondary to Neurofibromatosis Type 1

Semin Pediatr Neurol. 2017 May;24(2):92-99. doi: 10.1016/j.spen.2017.04.006. Epub 2017 Apr 10.

Authors

Shannon Jeanine Beres¹, Robert A Avery²

Affiliations

¹ Department of Neurology, Stanford University, Palo Alto, CA. Electronic address: sberes@stanford.edu.
² Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, PA; Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

PMID: 28941532
DOI: 10.1016/j.spen.2017.04.006

Abstract

Children with neurofibromatosis type 1 frequently manifest optic pathway gliomas-low-grade gliomas intrinsic to the visual pathway. This review describes the molecular and genetic mechanisms driving optic pathway gliomas as well as the clinical symptoms of this relatively common genetic condition. Recommendations for clinical management and descriptions of the newest imaging techniques are discussed.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Humans
Neurofibromatosis 1 / complications*
Neurofibromatosis 1 / genetics
Neurofibromatosis 1 / metabolism
Neurofibromatosis 1 / therapy
Neuroimaging
Optic Nerve Glioma / complications*
Optic Nerve Glioma / genetics
Optic Nerve Glioma / metabolism
Optic Nerve Glioma / therapy

Grants and funding

K23 EY022673/EY/NEI NIH HHS/United States