Total Synthesis of Repeating Unit of O-Polysaccharide of Providencia alcalifaciens O22 via One-Pot Glycosylation

Org Lett. 2017 Oct 6;19(19):5466-5469. doi: 10.1021/acs.orglett.7b02791. Epub 2017 Sep 26.

Abstract

The first total synthesis of the phosphorylated trisaccharide repeating unit of Providencia alcalifaciens O22 is reported. The trisaccharide contains rare deoxyamino sugar AAT at the reducing end and d-glyceramide 2-phosphate at the other end. The efficient synthesis involves one-pot assembly of trisaccharide and late-stage phosphorylation as key steps.

Publication types

  • Research Support, Non-U.S. Gov't