Phosphinoyl Radical Initiated Vicinal Cyanophosphinoylation of Alkenes

Org Lett. 2017 Oct 20;19(20):5537-5540. doi: 10.1021/acs.orglett.7b02621. Epub 2017 Oct 2.

Abstract

A double-functionalization reaction of alkenes through Mn(OAc)3-mediated phosphinoyl radical addition followed by CuCN-catalyzed cyanation is introduced. This one-pot reaction is performed under mild conditions to afford vicinal cyanophosphinoylation products.

Publication types

  • Research Support, Non-U.S. Gov't