Sudden Death Secondary to an Undiagnosed B-Cell Lymphoma of the Hypopharynx and Infiltration of the Inferior Constrictor Muscle

J Forensic Sci. 2018 Jul;63(4):1303-1306. doi: 10.1111/1556-4029.13663. Epub 2017 Oct 3.

Abstract

The aim of this presentation was to share an uncommon form of sudden death, suffered by a 64-year-old woman, due to a mechanical obstruction of hypopharynx by an undiagnosed B-cell lymphoma, infiltrating the inferior pharyngeal constrictor muscle. A forensic approach by means of scene investigation, circumstantial data collection, autopsy, and histological and toxicological investigations led to conclude that the cause of death was asphyxia, correlated with B-cell lymphoma of the hypopharynx. The autopsy examination highlighted the presence of a wall thickening, infiltrating, and projecting into the hypopharynx lumen. The histological analysis showed the essential finding of a B-cell lymphoma of the hypopharynx, diffusely infiltrating the inferior pharyngeal constrictor muscle. To conclude, this case demonstrates once more that in the absence of specific data, a thorough forensic investigation including autopsy, histological examination, and circumstantial data collection is mandatory to reach a correct cause of death.

Keywords: B-cell lymphoma; asphyxia; forensic science; hypopharynx; inferior constrictor muscle; sudden death.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / etiology*
  • Death, Sudden / etiology*
  • Female
  • Humans
  • Hypopharyngeal Neoplasms / pathology*
  • Lymphoma, B-Cell / pathology*
  • Middle Aged
  • Neoplasm Invasiveness
  • Pharyngeal Muscles / pathology*