Pathological discrepancy between colposcopic directed cervical biopsy and Loop Electrosurgical-Excision Procedures (LEEPs) in patients with biopsies proven high grade cervical intraepithelial neoplasia

Abstract

Objective: To determine the prevalence of patients with CIN1 or less from LEEP specimens in patients with colposcopic biopsy proven CIN2 or 3.

Materials and methods: This study was a retrospective-descriptive chart review. Clinical data were retrieved from medical records of women with CIN2 or 3 from colposcopic biopsy who subsequently underwent LEEP procedure between 2004 and 2014. All pathological slides were reviewed by the gynecologic pathologist. Statistical analyses were performed.

Results: Of 210 patients, 14 patients were excluded from the study. 196 patients were in eligible criteria and data were analyzed. There were 32 patients (16.3%) with CIN1 or less from LEEP specimens who previously had colposcopic biopsies proven CIN2 or 3. Only CIN2 from biopsy was the statistically significant risk factor of CIN1 or less in LEEP specimens. Odds ratio was 10.45 (95% confidence interval: 3.28-33.33, P < 0.001).

Conclusion: The prevalence of patients with CIN1 or less from LEEP specimens who previously had colposcopic biopsies proven CIN2 or 3 was 16.3%. CIN2 from biopsy was the statistically significant risk factor of CIN1 or less in LEEP specimens.

Keywords: Cervical biopsy; Cervical intraepithelial neoplasia; LEEP.