Prompt detection of L-asparaginase inactivation is crucial to optimize treatment efficacy also in aggressive lymphomas

Hematol Oncol. 2018 Apr;36(2):498-499. doi: 10.1002/hon.2484. Epub 2017 Oct 20.

Affiliations

¹ Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Ospedale Policlinico San Martino, IRCCS per l'OncologiaT, Genoa, Italy.
² Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

PMID: 29052244
DOI: 10.1002/hon.2484

No abstract available

Keywords: L-asparaginase; aggressive lymphoma; silent inactivation.

Publication types

Case Reports
Letter

MeSH terms

Adult
Asparaginase / administration & dosage*
Asparaginase / adverse effects
Asparaginase / pharmacokinetics*
Humans
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Lymphoma, T-Cell / drug therapy*
Lymphoma, T-Cell / pathology
Male
Splenic Neoplasms / drug therapy*
Splenic Neoplasms / pathology

Substances

Asparaginase