Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Enrico Collantoni; Marco Solmi; Davide Gallicchio; Paolo Santonastaso; Paolo Meneguzzo; Andrè F Carvalho; Brendon Stubbs; Maurizio Clementi; Claudia Pinato; Monica Forzan; Matteo Cassina; Francesca Fontana; Ivana Piva; Roberta Siani; Pierandrea Salvo; Elena Tenconi; Nicola Veronese; Christoph U Correll; Angela Favaro

doi:10.1002/erv.2555

Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

Eur Eat Disord Rev. 2017 Nov;25(6):524-532. doi: 10.1002/erv.2555.

Authors

Enrico Collantoni^{1

2}, Marco Solmi^{1

2}, Davide Gallicchio^{1

2}, Paolo Santonastaso^{1

2

3}, Paolo Meneguzzo^{1

2}, Andrè F Carvalho⁴, Brendon Stubbs^{5

6

7}, Maurizio Clementi⁸, Claudia Pinato⁸, Monica Forzan⁸, Matteo Cassina⁸, Francesca Fontana², Ivana Piva², Roberta Siani², Pierandrea Salvo², Elena Tenconi^{1

2

3}, Nicola Veronese⁹, Christoph U Correll^{10

11}, Angela Favaro^{1

2

3}

Affiliations

¹ Neuroscience Department, University of Padua, Italy.
² BIO.VEDA Group (Biobanca Veneta per i Disturbi dell'Alimentazione: Biobank of the Veneto Region Eating Disorders Units), Italy.
³ Centro Neuroscienze Cognitive (CNC), University of Padua, Italy.
⁴ Translational Psychiatry Research Group, Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Brazil.
⁵ Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
⁶ Physiotherapy Department, South London and Maudsley NHS Foundation Trust, UK.
⁷ Faculty of Health, Social Care and Education, Anglia Ruskin University, UK.
⁸ Clinical Genetics Unit, Department of Woman and Child Health, University of Padua, Italy.
⁹ National Research Council, Ageing Section, Italy.
¹⁰ Department of Psychiatry Research, Northwell Health, The Zucker Hillside Hospital, Glen Oaks, NY, USA.
¹¹ Department of Psychiatry and Molecular Medicine Hempstead, Hofstra Northwell School of Medicine, Hempstead, NY, USA.

PMID: 29057600
DOI: 10.1002/erv.2555

Abstract

Objectives: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).

Methods: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.

Results: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I² = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I² = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I² = 0-44%).

Conclusions: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Keywords: Val158Met; anorexia nervosa; bulimia nervosa; catechol-O-methyltransferase (COMT); polymorphism.

Publication types

Meta-Analysis

MeSH terms

Anorexia Nervosa / genetics
Biological Specimen Banks
Bulimia Nervosa / genetics
Case-Control Studies
Catechol O-Methyltransferase / genetics*
Feeding and Eating Disorders / genetics*
Gene Frequency
Genotype
Humans
Polymorphism, Single Nucleotide*

Substances

Catechol O-Methyltransferase