Pilot Study of a Tailored Smoking Cessation Intervention for Individuals in Treatment for Opioid Dependence

Nicotine Tob Res. 2018 Aug 14;20(9):1152-1156. doi: 10.1093/ntr/ntx189.

Abstract

Introduction: Over 85% of opioid-dependent individuals in methadone treatment smoke cigarettes; however, smoking cessation interventions are minimally effective in this population. To better help opioid-dependent individuals quit smoking, we developed and pilot-tested an intervention, based in the Information-Motivation-Behavioral Skills (IMB) model of behavior change, which could be tailored to address individual barriers to smoking cessation in this population.

Methods: We randomized participants (n = 83) in methadone treatment to the eight-session, IMB model-based, intervention plus nicotine replacement therapy (intervention, n = 41) or a facilitated referral to the state Quitline (control, n = 42). All participants completed assessments at baseline, 3 months, and 6 months.

Results: Intervention participants completed a median of five sessions (interquartile range [IQR] 3-8) and had significantly higher intervention satisfaction than control participants. Intervention participants reported smoking significantly fewer cigarettes per day at 3 months (median [IQR] = 6 [4-15]) and 6 months (median [IQR] = 8 [4-14]) as compared control participants at 3 months (median [IQR] = 10 [5-20]) and 6 months (median [IQR] = 10 [6-20]). Fifty-six percent of the intervention group and 41% of the control group a made a quit attempt during the study (p = .16). At 3 months, 7% (n = 3) of intervention participants and none of the control participants were abstinent from smoking (p = .23). At 6 months, 2% of participants in both groups were abstinent. Twenty-four percent and 10% of the intervention and control group participants, respectively, reported 20 or more smoke-free days (p = .43).

Conclusions: An IMB model-based smoking cessation intervention for opioid-dependent smokers is feasible and acceptable in methadone treatment and may help methadone maintained smokers cut down on their smoking.

Implications: This is the first study of a tailored, IMB Model-based, smoking cessation intervention for opioid dependent smokers. Results showed that opioid dependent smokers are willing and able to participate in an IMB model-based smoking cessation intervention, and this intervention may help this population cut down on their smoking. Also, the Quitline seems less feasible and acceptable for this population than a face-to-face intervention. Further research is needed to determine how to integrate smoking cessation treatment into methadone programs and how to improve interventions so that treatment gains can lead to long-term abstinence in this population.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Analgesics, Opioid / adverse effects
  • Behavior Therapy / methods
  • Female
  • Humans
  • Male
  • Methadone / therapeutic use
  • Middle Aged
  • Nicotine / administration & dosage
  • Opiate Substitution Treatment / methods*
  • Opiate Substitution Treatment / psychology
  • Opioid-Related Disorders / epidemiology*
  • Opioid-Related Disorders / psychology
  • Opioid-Related Disorders / therapy*
  • Pilot Projects
  • Smokers / psychology
  • Smoking Cessation / methods*
  • Smoking Cessation / psychology
  • Tobacco Use Cessation Devices
  • Tobacco Use Disorder / epidemiology*
  • Tobacco Use Disorder / psychology
  • Tobacco Use Disorder / therapy*

Substances

  • Analgesics, Opioid
  • Nicotine
  • Methadone