AtHKT1 drives adaptation of Arabidopsis thaliana to salinity by reducing floral sodium content

PLoS Genet. 2017 Oct 30;13(10):e1007086. doi: 10.1371/journal.pgen.1007086. eCollection 2017 Oct.

Abstract

Arabidopsis thaliana high-affinity potassium transporter 1 (AtHKT1) limits the root-to-shoot sodium transportation and is believed to be essential for salt tolerance in A. thaliana. Nevertheless, natural accessions with 'weak allele' of AtHKT1, e.g. Tsu-1, are mainly distributed in saline areas and are more tolerant to salinity. These findings challenge the role of AtHKT1 in salt tolerance and call into question the involvement of AtHKT1 in salinity adaptation in A. thaliana. Here, we report that AtHKT1 indeed drives natural variation in the salt tolerance of A. thaliana and the coastal AtHKT1, so-called weak allele, is actually hyper-functional in reducing flowers sodium content upon salt stress. Our data showed that AtHKT1 positively contributes to saline adaptation in a linear manner. Forward and reverse genetics analysis established that the single AtHKT1 locus is responsible for the variation in the salinity adaptation between Col-0 and Tsu-1. Reciprocal grafting experiments revealed that shoot AtHKT1 determines the salt tolerance of Tsu-1, whereas root AtHKT1 primarily drives the salt tolerance of Col-0. Furthermore, evidence indicated that Tsu-1 AtHKT1 is highly expressed in stems and is more effective compared to Col-0 AtHKT1 at limiting sodium flow to the flowers. Such efficient retrieval of sodium to the reproductive organ endows Tsu-1 with stronger fertility compared to Col-0 upon salt stress, thus improving Tsu-1 adaptation to a coastal environment. To conclude, our data not only confirm the role of AtHKT1 in saline adaptation, but also sheds light on our understanding of the salt tolerance mechanisms in plants.

MeSH terms

  • Adaptation, Physiological / genetics*
  • Alleles
  • Arabidopsis / genetics*
  • Arabidopsis / metabolism
  • Arabidopsis Proteins / genetics*
  • Cation Transport Proteins / genetics*
  • Flowers / genetics*
  • Gene Expression Regulation, Plant / genetics
  • Salinity
  • Salt Tolerance / genetics*
  • Sodium / metabolism*
  • Sodium Chloride / metabolism
  • Symporters / genetics*

Substances

  • Arabidopsis Proteins
  • Cation Transport Proteins
  • HKT1 protein, Arabidopsis
  • Symporters
  • Sodium Chloride
  • Sodium

Grants and funding

This study was funded by the Natural Science Foundation of China (http://www.nsfc.gov.cn/, 31422007 to DYC and 31500994 to DA), Chinese Thousand Talents Program grant (http://www.1000plan.org/, to DYC) Chinese Academy of Sciences (http://www.cas.cn/, XDPB0402 to DYC)and National Key Laboratory of Plant Molecular Genetics (http://www.nlpmg.ac.cn/, to DYC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.