Clinical Applications of Sublingual Immunotherapy

Thomas S Edwards; Sarah K Wise

doi:10.1016/j.otc.2017.08.010

Clinical Applications of Sublingual Immunotherapy

Otolaryngol Clin North Am. 2017 Dec;50(6):1121-1134. doi: 10.1016/j.otc.2017.08.010.

Authors

Thomas S Edwards¹, Sarah K Wise²

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Emory Sinus, Nasal and Allergy Center, Emory University, 550 Peachtree Street Northeast, MOT 11th Floor, Atlanta, GA 30308, USA.
² Department of Otolaryngology-Head and Neck Surgery, Emory Sinus, Nasal and Allergy Center, Emory University, 550 Peachtree Street Northeast, MOT 11th Floor, Atlanta, GA 30308, USA. Electronic address: skmille@emory.edu.

PMID: 29103453
DOI: 10.1016/j.otc.2017.08.010

Abstract

Sublingual immunotherapy (SLIT) is effective for the treatment of allergic rhinitis and allergic asthma in adults and children. In a limited number of studies, SLIT efficacy has been demonstrated for the treatment of food allergy. SLIT has a higher safety profile versus subcutaneous immunotherapy, although some systemic reactions have been reported. Appropriate patient selection, meticulous patient education, and routine follow-up are key for the safe and effective administration of SLIT. With organization and attention to detail, adding SLIT to one's practice can provide a highly valued patient service.

Keywords: Allergic asthma; Allergic rhinitis; Allergy; Asthma; Atopic dermatitis; Food allergy; Immunotherapy; Sublingual immunotherapy.

Publication types

Review

MeSH terms

Administration, Sublingual
Adult
Allergens / administration & dosage*
Child
Dermatitis, Atopic / therapy*
Food Hypersensitivity / therapy*
Humans
Patient Education as Topic
Patient Selection
Randomized Controlled Trials as Topic
Rhinitis, Allergic / therapy*
Sublingual Immunotherapy*

Substances

Allergens