68Gallium-Prostate-Specific Membrane Antigen PET/Computed Tomography for Primary and Secondary Staging in Prostate Cancer

Urol Clin North Am. 2017 Nov;44(4):557-563. doi: 10.1016/j.ucl.2017.07.004.

Abstract

Prostate-specific membrane antigen (PSMA) PET has been recently introduced for the diagnosis of patients with metastatic prostate cancer (PCa). Until today, staging of patients with PCa relied mostly on morphologic features, such as size or shape, resulting in low detection rates in disease recurrence. PSMA PET imaging provides molecular information and, in combination with conventional imaging, offers improved sensitivity and specificity. This review discusses the benefits and limitations of PSMA imaging in the setting of primary staging and detection of recurrent disease in comparison with standard-of-care imaging techniques.

Keywords: Biochemical recurrence; PET/CT; PSMA; Prostate cancer staging.

Publication types

  • Review

MeSH terms

  • Antigens, Surface / pharmacology*
  • Glutamate Carboxypeptidase II / pharmacology*
  • Humans
  • Male
  • Neoplasm Staging / methods*
  • Positron Emission Tomography Computed Tomography / methods*
  • Preoperative Period
  • Prostatic Neoplasms / diagnosis*
  • Radiopharmaceuticals / pharmacology

Substances

  • Antigens, Surface
  • Radiopharmaceuticals
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II