Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults

Sci Rep. 2017 Nov 6;7(1):14547. doi: 10.1038/s41598-017-12587-x.

Abstract

Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle-brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29-1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73-1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Ankle Brachial Index
  • Aorta, Abdominal / pathology*
  • China / epidemiology
  • Female
  • Humans
  • Hypertension / etiology*
  • Hypertension / pathology
  • Leg / blood supply*
  • Logistic Models
  • Male
  • Middle Aged
  • Peripheral Arterial Disease / epidemiology
  • Peripheral Arterial Disease / etiology*
  • Peripheral Arterial Disease / pathology
  • Prevalence
  • Risk Factors