Mind Your Cs and Gs

Oliver I Fregoso

doi:10.1016/j.chom.2017.10.012

Mind Your Cs and Gs

Cell Host Microbe. 2017 Nov 8;22(5):575-576. doi: 10.1016/j.chom.2017.10.012.

Author

Oliver I Fregoso¹

Affiliation

¹ Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: ofregoso@mednet.ucla.edu.

PMID: 29120736
DOI: 10.1016/j.chom.2017.10.012

Abstract

How can an innate immune sensor shape viral evolution? In recent work, Takata et al. (2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self. This pressure may have driven CG dinucleotide suppression in HIV-1 and other RNA viruses to evade host antiviral defenses.

Publication types

Comment

MeSH terms

Antiviral Agents
HIV-1*
Humans
Immunity, Innate / immunology
RNA Viruses / genetics
Virus Replication / drug effects*

Substances

Antiviral Agents