Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin

J P Wolf; M Sinosich; T L Anderson; A Ulmann; E E Baulieu; G D Hodgen

doi:10.1016/0002-9378(89)90084-7

Progesterone antagonist (RU 486) for cervical dilation, labor induction, and delivery in monkeys: effectiveness in combination with oxytocin

Am J Obstet Gynecol. 1989 Jan;160(1):45-7. doi: 10.1016/0002-9378(89)90084-7.

Authors

J P Wolf¹, M Sinosich, T L Anderson, A Ulmann, E E Baulieu, G D Hodgen

Affiliation

¹ Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Medical College of Hampton Roads, Norfolk 23510.

PMID: 2912101
DOI: 10.1016/0002-9378(89)90084-7

Abstract

A progesterone antagonist (RU 486), combined with oxytocin, was effective in achieving cervical dilation, labor induction, and early delivery in near-term monkeys. Effects of RU 486 included accelerated flow of colostrum and transiently enhanced weight gain in infants. No overt toxicity on fetuses, mothers, or newborns was detected with the use of a single oral dose of 25 mg.

MeSH terms

Animals
Cervix Uteri / drug effects*
Colostrum / immunology
Colostrum / metabolism
Drug Therapy, Combination
Estrenes / pharmacology
Estrenes / therapeutic use*
Female
Immunoglobulins / analysis
Labor, Induced / methods*
Lactation / drug effects
Macaca fascicularis
Mifepristone
Oxytocin / pharmacology
Oxytocin / therapeutic use*
Pregnancy
Progesterone / antagonists & inhibitors*
Weight Gain

Substances

Estrenes
Immunoglobulins
Mifepristone
Progesterone
Oxytocin